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Evolving rrRCC Management
The Management of rrRCC
Is Rapidly Evolving
There is a lack of phase 3 data
beyond second line
Making clinical decisions is challenging in this rapidly changing field12
As a result of recent improvements in overall survival, there is a growing population of patients with highly refractory disease who have received prior checkpoint inhibitors and need new later-line treatment options13,14
Later-Line RCC Therapy Has Proven Benefits
Post−second-line treatment can offer meaningful efficacy
A retrospective analysis of treatment of 4824 International Metastatic Renal Cell Carcinoma Database Consortium patients found that mRCC patients who received third-line therapy had an increased median survival approximately twice that of those who did not receive treatment (14.9 vs 7.6 months, respectively).2
“The tolerability [of regimens] is an issue when considering third- and fourth-line therapies. By the fourth line, most patients are just beaten up by treatment, so you can only really discuss hospice care.”
– Community Oncologist
Third-Line Targeted Therapy
Demonstrated Improved Survival2*
*Versus no therapy.
Reprinted from European Urology, 71(2), Wells JC, Stukalin I, Norton C, et al. Third-line targeted therapy in metastatic renal cell carcinoma: results from the International Metastatic Renal Cell Carcinoma Database Consortium, 204-220, 2017, with permission from Elsevier.
Kaplan-Meier curve showing OS from time of cessation of second-line therapy for patients receiving third-line therapy (n=715) or not (n=345), excluding patients who died within 3 months of cessation.
CI=confidence interval; OS=overall survival; rrRCC=relapsed/refractory renal cell carcinoma.